AbstractMutations in 13 genes with temperature‐sensitive (ts), flightless phenotypes have been examined. All hop and fly well when raised at the permissive temperature, but fly poorly, or not at all, when raised at the restrictive temperature. The mutations were divided into three groups on the basis of their temperature‐sensitive periods (TSPs) for flightlessness. The TSPs for mutations at five loci,fli‐C1, D1, E1, I1, andshak A1, in the first group are confined to 24 to 48 hr interval during early pupal development. Mutations in the second group, includingeag101,fli B1, andfuts1have continuous TSPs 3 to 4 days in length, extending from late larval through the early pupal stages. The flight TSPs for mutations in the third class, includingfli J1,fli K2,flrd H3, andflrd N1, are almost continuous, and span most of the larval and pupal periods. Many of the mutations have pleiotropic phenotypes, including semilethality and lethality, and wing posture and cuticle abnormalities, with discernible TSPs. One of the more intriguing pleiotropic phenotypes is the ts optomotor response exhibited byfli J2, the TSP for which extends from late larval through late pupal s
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