...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of applied toxicology >Neurodevelopmental toxicity of pyrazinamide to larval zebrafish and the restoration after intoxication withdrawal
【24h】

Neurodevelopmental toxicity of pyrazinamide to larval zebrafish and the restoration after intoxication withdrawal

机译：Neurodevelopmental toxicity of pyrazinamide to larval zebrafish and the restoration after intoxication withdrawal

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Abstract To investigate the neurotoxicity of pyrazinamide (PZA) to larval zebrafish, the PZA effects were assessed followed by its mechanism being explored. Same as isoniazid (INH), this compound is a first‐line anti‐tuberculosis drug and is suggested to be a risk that inducing nerve injury with long‐term intoxication. Our findings indicated that zebrafish larvae obtained severe nerve damage secondary to constant immersion in various concentrations of PZA (i.e., 0.5, 1.0, and 1.5?mM) from 4?hpf (hours post fertilization) onwards until 120?hpf. The damage presented as dramatically decrease of locomotor capacity and dopaminergic neuron (DAN)‐rich region length in addition to defect of brain blood vessels (BBVs). Moreover, PZA‐administrated zebrafish showed a decreased dopamine (DA) level and downregulated expression of neurodevelopment‐related genes, such as shha, mbp, neurog1, and gfap. However, secondary to 48‐h restoration in fish medium (i.e., at 168?hpf), the neurotoxicity described above was prominently ameliorated. The results showed that PZA at the concentrations we tested was notably neurotoxic to larval zebrafish, and this nerve injury was restorable after PZA withdrawing. Therefore, this finding will probably provide a reference for clinical medication.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号