SummaryBackgroundMajor cat allergenFel dI is produced consistently by skin and by sebaceous glands before being spread on the fur.ObjectiveSince cats have tubular anal glands secreting sebum, proteins and lipids, we looked at the possible presence ofEel dI in these secretions and compared the levels found to those already reported in other cat tissues or secretions.MethodsThirty‐seven cats were studied.Eel dI dosage in the anal sacs’ secretions was performed using an enzyme linked immunosorbent assay (ELISA) method and total protein evaluation by the Bradford's method.ResultsThe geometric meanEel dI concentration was 41 U/g secretion which represents 3.4 of the total protein levels. This amount is the highest ever reported in cat tissues or secretions.ConclusionThe close association ofEel dI protein with skin sebaceous glands and anal sacs both with holocrine function and lipids’ secretions in one hand, and the homology of chain I ofEel dI with some steroid‐binding proteins in other hand, suggest a possible physiological role forEel dI in the regulation of lipids on skin and
展开▼
