Maternal-fetal cholesterol transport in the second half ofmouse pregnancy does not involve LDL receptor-related protein 2

Zwier M. V.; Baardman M. E.; van Dijk T. H.Jurdzinski A.Wisse L. J.Bloks V. W.Berger R. M. F.DeRuiter M. C.Groen A. K.Plosch T.

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Maternal-fetal cholesterol transport in the second half ofmouse pregnancy does not involve LDL receptor-related protein 2

机译：Maternal-fetal cholesterol transport in the second half ofmouse pregnancy does not involve LDL receptor-related protein 2

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摘要

AimLDL receptor-related protein type 2 (LRP2) is highly expressed on both yolk sac and placenta. Mutations in the corresponding gene are associated with severe birth defects in humans, known as Donnai-Barrow syndrome. We here characterized the contribution of LRP2 and maternal plasma cholesterol availability to maternal-fetal cholesterol transport and fetal cholesterol levels in utero in mice.

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来源
《Acta physiologica》 |2017年第4期|471-485|共15页
作者
Zwier M. V.; Baardman M. E.; van Dijk T. H.Jurdzinski A.Wisse L. J.Bloks V. W.Berger R. M. F.DeRuiter M. C.Groen A. K.Plosch T.;
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作者单位

Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Ctr Congenital Heart Dis, Groningen;

Leiden Univ, Med Ctr, Dept Anat & Embryol, Leiden, Netherlands;

Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, Groningen, NetherlandsUniv Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynaecol, Groningen, NetherlandsUniv Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands;

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原文格式 PDF
正文语种英语
中图分类人体生理学;
关键词
cholesterol; fetus; lipoprotein; placenta; transport;

Maternal-fetal cholesterol transport in the second half ofmouse pregnancy does not involve LDL receptor-related protein 2

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