Sampling modality influences the predictive value of grading in adult soft tissue extremity sarcomas

KhojaH.; GriffinA.; DicksonB.WunderJ.FergusonP.HowarthD.KandelR.

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Sampling modality influences the predictive value of grading in adult soft tissue extremity sarcomas

机译：Sampling modality influences the predictive value of grading in adult soft tissue extremity sarcomas

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Context: Histologic grade is one of the best predictors of outcome in adult soft tissue sarcomas. Current grading systems were validated on resection specimens; however, there has been a trend toward the use of biopsies to diagnosis these tumors. Objectives.-To determine whether the grade of an extremity soft tissue sarcoma determined on tissue obtained by either core needle biopsy or incisional biopsy is predictive of metastasis- or disease-free survival, and whether either sampling modality is superior. Design: One hundred three core needle biopsies and 107 incisional biopsies of nonmetastatic spindle cell sarcomas of the extremities were retrieved from the archives. All cases had a minimum 2-year follow-up. Patient data and outcome and tumor characteristics were recorded. Tumors were reviewed and evaluated using the French Federation of Cancer Centers Sarcoma Group grading system. Kaplan-Meier survival curves were generated to correlate tumor grade with metastasis- and diseasefree survival for both groups. Results: Patient and tumor characteristics were similar between groups except that more tumors were grade 3 and superficial in the incisional biopsy group. Grade determined on core needle biopsy was not predictive of either metastasis-free survival (P=.59) or disease-free survival (P =.50). In contrast, grade determined on incisional biopsy was predictive of both metastasis-free survival (P <.001) and disease-free survival (P =.001). Conclusions: Biopsy, particularly core needle biopsy, represents a convenient diagnostic tool, particularly in the context of neoadjuvant therapy. However, based on these results incisional biopsy is recommended if grading is to be used to predict prognosis in spindle cell soft tissue sarcomas of the extremities.

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《Archives of pathology & laboratory medicine》 |2013年第12期|1774-1779|共6页
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KhojaH.; GriffinA.; DicksonB.WunderJ.FergusonP.HowarthD.KandelR.;
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Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, Toronto;

Department of Orthopaedic Surgery, Mount Sinai Hospital, Toronto, ON, Canada;

Department of Orthopaedic Surgery, Mount Sinai Hospital, Toronto, ON, Canada, Department of Surgery;

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Sampling modality influences the predictive value of grading in adult soft tissue extremity sarcomas

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