CTNNB1, encoding (J-catenin, is frequently mutated in hepatocellular carcinoma, the most rapidly growing solid cancer in the US, and activating mutations in this gene are associated with increased expression of glutamine synthetase. A new report by Adebayo Michael et al. (2019) identifies mTOR as a direct target of WNT/p-catenin signaling through increased production of glutamine, which is required for the carcinogenic effects of WNT/p-catenin activity in the liver.
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