Relationship between serum pro- and anti-inflammatory cytokine and growth factor concentrations with the age and gender adjusted prevalence of diabetes and pre-diabetes

Elahe Mahdipour; Maryam Azizian; Seyed Reza MirhafezShiva GanjaliSara ShoeibiMohsen NematyHabibollah EsmailyGordon AA FernsMajid Ghayour Mobarhan

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Relationship between serum pro- and anti-inflammatory cytokine and growth factor concentrations with the age and gender adjusted prevalence of diabetes and pre-diabetes

机译：Relationship between serum pro- and anti-inflammatory cytokine and growth factor concentrations with the age and gender adjusted prevalence of diabetes and pre-diabetes

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Abstract The main goal of the present study is to compare the serum pro- and anti-inflammatory cytokines and growth factor profile (IL-1α, IL-1β, IL-2, IL-6, IL-8, IFN-γ, MCP-1, TNF-α, IL-10, IL-4, VEGF, and EGF) in individuals with diabetes or pre-diabetes and control subjects matched for age and gender. This study included 270 normal control subjects, 41 pre-diabetics, and 104 diabetic subjects. Demographic and anthropometric characteristics and serum biochemistry parameters, smoking status, and blood pressure were determined. Serum cytokine and growth factor measurements were performed using a multiplex biochip array based method. After removing the effects of confounders such as age, sex, smoking, BMI, serum triglyceride and cholesterol, hypertension, and treatment with anti-diabetic drugs, serum IL-4 ( p ?=?0.015), IL-1α ( p ?=?0.031), and VEGF ( p ?=?0.012) were significantly associated with the presence of diabetes mellitus. The presence of pre-diabetes was positively associated with serum IL-4 ( p ? p ?=?0.026). We have found a positive association between serum IL-1α, and IL-4, and a negative association of serum VEGF with the presence of diabetes, or pre-diabetes.

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《International journal of diabetes in developing countries.》 |2017年第3期|313-319|共7页
作者
Elahe Mahdipour; Maryam Azizian; Seyed Reza MirhafezShiva GanjaliSara ShoeibiMohsen NematyHabibollah EsmailyGordon AA FernsMajid Ghayour Mobarhan;
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Medical Genetics Research Center, School of Medicine, Mashhad University of Medical Sciences;

Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences;

Department of Basic Medical Sciences, Neyshabur University of Medical SciencesDepartment of Medical Biotechnology, School of Medicine, Mashhad University of Medical SciencesDepartment of Biostatistics, Mashhad University of Medical SciencesDivision of Medical Education, Brighton and Sussex Medical SchoolCardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences;

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正文语种英语
中图分类内分泌腺疾病及代谢病;
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Diabetes; Pre-diabetes; Inflammatory cytokine; Anti-inflammatory cytokine;

Relationship between serum pro- and anti-inflammatory cytokine and growth factor concentrations with the age and gender adjusted prevalence of diabetes and pre-diabetes

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