The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates

SantnerT.; SiegmundV.; MarxA.MicuraR.

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The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates

机译：The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates

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摘要

Modified nucleoside triphosphates (NTPs) represent powerful building blocks to generate nucleic acids with novel properties by enzymatic synthesis. We have recently demonstrated the access to 2′-SeCH 3-uridine and 2′-SeCH 3-cytidine derivatized RNAs for applications in RNA crystallography, using the corresponding nucleoside triphosphates and distinct mutants of T7 RNA polymerase. In the present note, we introduce the chemical synthesis of the novel 2′-methylseleno-2′-deoxyadenosine and -guanosine 5′-triphosphates (2′-SeCH 3-ATP and 2′-SeCH 3-GTP) that represent further candidates for the enzymatic RNA synthesis with engineered RNA polymerases.

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《Bioorganic and medicinal chemistry》 |2012年第7期|2416-2418|共3页
作者
SantnerT.; SiegmundV.; MarxA.MicuraR.;
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作者单位

Institute of Organic Chemistry, Center for Molecular Biosciences CMBI, University of Innsbruck;

Department of Chemistry, Konstanz Research School Chemical Biology, University of Konstanz, 78457;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Crystallography; Nucleoside modifications; Nucleosides; RNA; Selenium;

The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates

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