Objective: To assess the prevalence, pattern and outcome of congenital heart disease (CHD) among the babies born in Bhabha Atomic Research Centre (BARC) Hospital, Mumbai and to compare the pattern of CHD with the study done in the same hospital in year 1999. Methods: A prospective, longitudinal study was conducted from January 2006 through December 2011. Babies presenting with murmur were closely followed up till the diagnosis and further to assess the outcome. 2-D Echocardiography was used as a diagnostic tool. Results: The overall prevalence of CHD was 13.28 per 1,000 live births. Ventricular septal defect (VSD) was the commonest CHD (42.86 ) followed by Atrial septal defect (ASD) (25.71 ) giving the prevalence of 5.69 and 3.41 per 1,000 live births respectively. Tetrology of Fallot's (TOF) was the main cyanotic CHD (8.57 ) with the prevalence of 1.13 per 1,000 live births. VSD and TOF were prevalent in males. ASD was prevalent in females. Associated structural anomalies were detected in 22.86 cases; Down's syndrome being the commonest.Spontaneous closure rate of 71.4 in muscular VSD and 50 in perimembranous VSD was observed. All small sized VSD's closed spontaneously and all large sized VSD's required surgical intervention. Spontaneous closure was observed in 44.44 of ASD cases. Overall, device closure was required in 17.14 and 25.71 underwent open heart surgery. Conclusions: The pattern of CHD has remained almost the same compared to the previous study. The outcome was excellent due to early diagnosis, regular follow up and timely intervention.
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