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首页> 外文期刊>Journal of Endocrinological Investigation: Official Journal of the Italian Society of Endocrinology >Relationship between thyroid-stimulating antibodies and thyrotropin-binding inhibitory immunoglobulins years after administration of radioiodine for Graves' disease: retrospective clinical survey.
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Relationship between thyroid-stimulating antibodies and thyrotropin-binding inhibitory immunoglobulins years after administration of radioiodine for Graves' disease: retrospective clinical survey.

机译：Relationship between thyroid-stimulating antibodies and thyrotropin-binding inhibitory immunoglobulins years after administration of radioiodine for Graves' disease: retrospective clinical survey.

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摘要

Thyroid-stimulating antibody (TSAb) activity and the TSH-binding inhibitory immunoglobulin (TBII) index were assessed in 158 patients with Graves' disease who had been treated with 131I 6-14 years earlier. Twenty-one patients (13) were still hyperthyroid, 45 (28) were euthyroid, 44 (28) were subclinically hypothyroid, and 48 (30) were overtly hypothyroid. Positive results were obtained in 10 (48) of the 21 patients with hyperthyroidism for both TSAb and TBII assays, and in 3 patients (14) in one of the assays. In contrast, only two (5) patients with subclinical hypothyroidism and 1 (2) patient with overt hypothyroidism tested positive in both assays, and 11 (25) subclinically hypothyroid patients and 15 (31) overtly hypothyroid patients tested positive in one of the assays. The correlation coefficients between TSAb and TBII were 0.88 (p 0.05) in patients with overt hypothyroidism. Findings indicate the presence of long-term changes in the population of TSH receptor antibodies years after 131I treatment, which may influence thyroid function.

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