首页>
外文期刊>Clinical and experimental allergy :
>Isotype specific immunoglobulin responses to the house dust miteDermatophagoides pteronyssinusand the purified allergenDer p1 in asthmatic and control subjects from the Eastern Highlands of Papua New Guinea
【24h】
Isotype specific immunoglobulin responses to the house dust miteDermatophagoides pteronyssinusand the purified allergenDer p1 in asthmatic and control subjects from the Eastern Highlands of Papua New Guinea
展开▼
机译：Isotype specific immunoglobulin responses to the house dust miteDermatophagoides pteronyssinusand the purified allergenDer p1 in asthmatic and control subjects from the Eastern Highlands of Papua New Guinea
SummaryThe IgG, IgE and IgA antibody responses to the whole mite extract and a purified major mite allergenDer p1, in sera from asthmatic and age‐ and sex‐matched control subjects from the South Fore region of the Eastern Highlands of Papua New Guinea, have been studied. Radio‐allergosorbent studies showed that the majority of the asthmatics, in contrast to control subjects, produced IgE to whole mite extract, and thatDer p1 was a major allergen in this population with 88 of mite allergic asthmatics responding. Enzyme‐linked immunosorbent assay studies on these sera showed that the geometric mean levels of whole mite, but notDer p1, specific IgG and IgA were significantly higher in the asthmatic group than in the control group. Significant correlations between whole mite specific IgG, IgE and IgA responses were obtained. These data indicate that Papua New Guinean asthmatics are similar to Caucasian asthmatic population with regard to serological responses to mite allergens, despite differences in disease presentation, particularly the late age of onset and severity of s
展开▼
