...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>the american journal of dermatopathology >Histogenetic Relations Between Giant Cell Fibroblastoma and Dermatofibrosarcoma ProtuberansCD34 Staining Showing the Spectrum and a Simulator
【24h】

Histogenetic Relations Between Giant Cell Fibroblastoma and Dermatofibrosarcoma ProtuberansCD34 Staining Showing the Spectrum and a Simulator

机译：Histogenetic Relations Between Giant Cell Fibroblastoma and Dermatofibrosarcoma ProtuberansCD34 Staining Showing the Spectrum and a Simulator

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

The authors describe three lesions that provide further evidence for a close, possibly histogenetic relation between giant cell fibroblastoma and dermatofibrosarcoma protuberans. The first case involves a dermatofibrosarcoma protuberans that contained a single giant cell fibroblastoma-like focus of multinucleate giant cells. A second tumor, a giant cell fibroblastoma, recurred 6 years later as a dermatofibrosarcoma protuberans. In the third lesion, there was a juxtaposition and co-mingling of dermatofibrosarcoma protuberans and giant cell fibroblastoma within the same primary lesion. In all cases, both the giant cell fibroblastoma areas and dermatofibrosarcoma protuberans areas stained positively with CD34. A fourth case, a dermatofibrosarcoma protuberans infiltrated skeletal muscle, creating giant cell fibroblastoma-like giant cell mimics-a result of skeletal muscle degeneration or atrophy with nuclear conglomeration. The latter giant cells failed to express CD34 but did show immunoreactivity with desmin. These findings support the concept that giant cell fibroblastoma and dermatofibrosarcoma protuberans probably represent a histologic spectrum of a single CD34 positive (perhaps, dermal dendrocytic) neoplasm, a conclusion supported by a recently cloned t(7;22) breakpoint demonstrated in both neoplasms.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号