Human Neuronal SHSY5Y Cells on PVDF: PTrFE Copolymer Thin Films

Tonazzini Ilaria; Bystrenova Eva; Chelli BeatriceGreco PierpaoloDe Leeuw DagoBiscarini Fabio

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Human Neuronal SHSY5Y Cells on PVDF: PTrFE Copolymer Thin Films

机译：Human Neuronal SHSY5Y Cells on PVDF: PTrFE Copolymer Thin Films

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Here, we investigate the in vitro biocompatibility of polyvinylidenefluoride (PVDF)-polytrifluoroethylene (PTrFE) copolymer thin films using neuronal cells. The aim is to obtain an optimal capping layer material for hybrid bio-organic electronic transducers based on organic electronic devices, which can be applied for bidirectional communication with the central nervous system. PVDF: PTrFE thin films were grown by spin coating and characterized by AFM. Human neuroblastoma SHSY5Y cells were used as neuronal model and their interaction with PVDF: PTrFE films was investigated in term of cell adhesion, proliferation, differentiation, and cytoskeleton organization. We show that PVDF: PTrFE thin films allowed standard SHSY5Y proliferation and neuronal differentiation, even if with reduced short-term cell adhesion and spreading.

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《Advanced Engineering Materials》 |2015年第7期|1051-1056|共6页
作者
Tonazzini Ilaria; Bystrenova Eva; Chelli BeatriceGreco PierpaoloDe Leeuw DagoBiscarini Fabio;
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Scuola Normale Super Pisa, Natl Enterprise NanoSci & NanoTechnol NEST, I-56127 Pisa, Italy;

CNR, ISMN, I-40129 Bologna, Italy;

Scriba Nanotecnol Srl, I-40129 Bologna, ItalyMax Planck Inst Polymer Forsch, D-55128 Mainz, Germany;

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正文语种英语
中图分类工程材料学;
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Human Neuronal SHSY5Y Cells on PVDF: PTrFE Copolymer Thin Films

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