Development and validation of a nomogram for predicting outcome of patients with vulvar cancer.

Rouzier R; Preti M; Haddad BMartin MMicheletti LPaniel BJ

首页> 外文期刊>Obstetrics and Gynecology: Journal of the American College of Obstetricians and Gynecologists >Development and validation of a nomogram for predicting outcome of patients with vulvar cancer.

【24h】

Development and validation of a nomogram for predicting outcome of patients with vulvar cancer.

机译：Development and validation of a nomogram for predicting outcome of patients with vulvar cancer.

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

OBJECTIVE: To construct and validate a nomogram to predict relapse-free survival of patients treated for vulvar cancer. METHODS: Data from 244 patients treated for vulvar cancer at a single institution (Creteil, France) were used as a training set to develop and calibrate a nomogram for predicting relapse-free survival and local relapse-free survival. We used bootstrap resampling for the internal validation and we tested the nomogram on an independent validation set of patients (Torino, Italy) for the external validation. RESULTS: The nomograms were based on a Cox proportional hazards regression model. Covariates for the relapse-free survival model included age, T stage, number of metastatic nodes, bilateral lymph node involvement, omission of the lymphadenectomy, margin status, lymphovascular space invasion, and depth of invasion. The concordance indices were 0.85 and 0.83 in the training set before and after bootstrapping, respectively, and 0.83 in the validation set. The predictions of our nomogram discriminated better than did the International Federation of Gynecology and Obstetrics stage (0.83 compared with 0.78, P = .01). The calibration of our nomogram was good. In the validation set, 2-year and 5-year relapse-free survival were well predicted with less than 5 difference between the predicted and observed survivals for each quartile. A nomogram for predicting local relapse was also developed. CONCLUSION: We have developed nomograms for predicting distant and local relapse of vulvar cancer at 2 and 5 years and validated them both internally and externally. These nomograms will be freely available on the International Society for the Study of Vulvovaginal Disease Web site. LEVEL OF EVIDENCE: III.

著录项

来源
《Obstetrics and Gynecology: Journal of the American College of Obstetricians and Gynecologists》 |2006年第3期|672-677|共6页
作者
Rouzier R; Preti M; Haddad BMartin MMicheletti LPaniel BJ;
展开▼
作者单位

Departments of Gynecology and Obstetrics and Oncology, Centre Hospitalier Intercommunal de Creteil, University Paris 12, Creteil, France;

and Department of Gynecology and Obstetrics, University of Torino, Torino, Italy.;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类妇产科学;
关键词
Cancer Relapse; CARCINOMA OF VULVA; survival aspects; Training; Models;

Development and validation of a nomogram for predicting outcome of patients with vulvar cancer.

摘要

著录项

相关主题

期刊订阅