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frizzledGene expression and development of tissue polarity in theDrosophilawing

机译：frizzledGene expression and development of tissue polarity in theDrosophilawing

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AbstractAlmost every cell in theDrosophilapupal wing forms a single, distally pointing cuticular hair. The function of thefrizzled (fz)gene is essential for the elaboration of the normal wing hair pattern. In the absence offzfunction hairs develop, but they display an abnormal polarity. We have examined the developmental expression of the fi gene at the RNA level via in situ hybridization and at the protein level via Western blotting. We have found thatfzis expressed in all regions of the epidermis before, during, and after thefzcold sensitive period. We have also found thatfzfunction is not required for normal fi expression. We have further found that mutations in several other tissue polarity genes do not noticeably alter the expression or the modification state of the Fz protein. © 1994 Wiley‐Liss, I

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