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首页> 外文期刊>Liver >Diagnosis of acute type B hepatitis by a solid phase u‐antibody capture radioimmunoassay for IgM class antibody to hepatitis B core antigen: a diagnostic proposal based on a prospective study
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Diagnosis of acute type B hepatitis by a solid phase u‐antibody capture radioimmunoassay for IgM class antibody to hepatitis B core antigen: a diagnostic proposal based on a prospective study

机译：Diagnosis of acute type B hepatitis by a solid phase u‐antibody capture radioimmunoassay for IgM class antibody to hepatitis B core antigen: a diagnostic proposal based on a prospective study

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ABSTRACT—The diagnostic and prognostic significance of IgM anti‐HBc, studied by a solid phase u‐antibody capture radioimmunoassay at a serum dilution of 1:4000, was prospectively evaluated in 73 adult patients with acute hepatitis seropositive for hepatitis B surface antigen (HBsAg). Of the 73 cases, 20 (27.4) cleared their HBsAg within 6 months, while the remaining 53 (72.6) did not. HBsAg seroconversion to its antibody occurred in 15 (93.8) of the 16 patients positive for IgM anti‐HBc with S/N ratios above 5.0, as did 5 (26.3) of the 19 with S/N ratios between 2.1 to 5.0, and none (0) of the 38 negative for IgM anti‐HBc (S/N ratios<2.1). Therefore, a S/N ratio of IgM anti‐HBc above 5.0 is diagnostic for acute type B hepatitis. However, low S/N ratios (2.1–5.0) of IgM anti‐HBc were observed in the early stage of some patients with acute type B hepatitis, and would increase to a level greater than 5.0 when assayed again 1–2 weeks later. It was therefore suggested that repeated testing of anti‐HBc IgM is mandatory for accurate diagnosis of acute type B hepatitis in patients whose initial serum specimens showed low S/N ratios of IgM anti‐HBc. According to this criterion, only 22 (30.1) of the 73 patients with acute hepatitis seropositive for HBsAg in Taiwan were true acute type B hepatitis, of whom 2 (9.1) subsequently became chronic HBsAg carriers, while the remaining 51 (69.9) were chronic HBsAg carriers with other superimposed forms of

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