SUMMARYStudies were carried out on 22 healthy male volunteers to investigate whether intravenous administration of either the opiate antagonist, naloxone, or the dopamine antagonist, domperidone, or the α2‐adrenoreceptor antagonist, idazoxan, could reverse the delay in gastric emptying induced by ileal infusion of lipid emulsion. Ileal infusion of 50 lipid emulsion signficantly delayed the rate of gastric emptying compared with ileal infusion of isotonic saline (P<0.01). Intravenous infusion of naloxone (20 μg kg−1hour−1) or prior administration of either intravenous domperidone (20 mg) or idazoxan (0.2 mg kg−1) did not inhibit the delay in gastric emptying induced by ileal infusion of lipid emulsion. These observations indicate that feedback regulation of gastric emptying by ileal lipid does not appear to be mediated by either dopaminergic or enkephalinergic neurons, nor by α2‐adr
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