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首页> 外文期刊>european journal of neuroscience >Ultrastructural Characterization of Adrenocorticotrope Hormone (ACTH) Immunoreactive Fibres in the Mesencephalic Central Grey Substance of the Rat
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Ultrastructural Characterization of Adrenocorticotrope Hormone (ACTH) Immunoreactive Fibres in the Mesencephalic Central Grey Substance of the Rat

机译：Ultrastructural Characterization of Adrenocorticotrope Hormone (ACTH) Immunoreactive Fibres in the Mesencephalic Central Grey Substance of the Rat

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AbstractThe fine structural localization of fibres immunoreactive for the adrenocorticotrope hormone (ACTH) was studied in the mesencephalic central grey substance (MCG) of the male Wistar rat. Light microscopically, varicose ACTH‐immunoreactive fibres were found throughout the MCG in a dorsal, lateral and ventral, periventricular position. Electron microscopically, the immunoreactivity was most prominent in the direct vicinity of electron‐dense secretory granules in axonal varicosities, and, although to a lower degree, around other cytoplasmic organelles such as electron‐lucent synaptic vesicles, mitochondria and microtubules. With serial section analysis two types of ACTH‐immunoreactive varicosity were discerned. The first type is large, contains many, small electron‐lucent synaptic vesicles, that are located in the vicinity of a morphologically well‐defined synaptic contact. In this type of varicosity, large dense‐core secretory granules are scarce. Immunoreactivity is low or absent, particularly near the active zone. The second type is strongly immunoreactive. It always contains many large, dense‐core secretory granules; electron‐lucent vesicles are rare. The smaller varicosities of this type never make synaptic contacts, but a few of the larger varicosities have synaptic contacts with dendr

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