This freeze-fracture study examined the structure of the axolemma of non-myelinated fibers in the optic disc region of the adult rat. Spatially heterogeneous patterns of intramembranous particles (IMPs) were observed on the E-fracture faces; particle distribution patterns ranged from clusters of4–7IMPs to linear arrays of particles 1–3 IMPs wide that apparently encircle the axon. These bands of particles displayed a periodicity of ∼0.16 μm. The present findings demonstrate that, in specialized regions, the axolemma of non-myelinated fibers not in the region of synapses can exhibit distinct spatial heterog
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