Thieno2,3-d pyrimidine as a promising scaffold in medicinal chemistry: Recent advances

Ali Eslam M. H.; Abdel-Maksoud Mohammed S.; Oh Chang-Hyun

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Thieno2,3-d pyrimidine as a promising scaffold in medicinal chemistry: Recent advances

机译：Thieno2,3-d pyrimidine as a promising scaffold in medicinal chemistry: Recent advances

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Thienopyrimidine scaffold is a fused heterocyclic ring system that structurally can be considered as adenine, the purine base that is found in both DNA and RNA-bioisosteres. Thienopyrimidines exist in three distinct isomeric forms. The current review discusses thieno2,3-d pyrimidine as a one of the opulent heterocycles in drug discovery. Its broad range of medical applications such as anticancer, anti-inflammatory, anti-microbial, and CNS protective agents has inspired us to study its structure-activity relationship (SAR), along with its relevant synthetic strategies. The present review briefly summarizes synthetic approaches for the preparation of thieno2,3-d pyrimidine derivatives. In addition, the promising biological activities of this scaffold are also illustrated with explanatory diagrams for their SAR studies.

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《Bioorganic and medicinal chemistry》 |2019年第7期|1159-1194|共36页
作者
Ali Eslam M. H.; Abdel-Maksoud Mohammed S.; Oh Chang-Hyun;
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作者单位

KIST, Ctr Biomat, Seoul 02792, South Korea;

NRC, Pharmaceut & Drug Ind Res Div, Med & Pharmaceut Chem Dept, Giza 12622, Egypt;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Thienopyrimidine; Anti-inflammatory; Anticancer; Antimicrobial; Antiviral; CNS protective agents;

Thieno2,3-d pyrimidine as a promising scaffold in medicinal chemistry: Recent advances

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