AbstractUptake of cadmium as109CdCl2,109Cd‐cysteine,109Cd‐albumin and109Cd‐metallothionein was studied in isolated kidney cells from rat. Cd as109CdCl2and109Cd‐albumin was taken up at similar rates. The uptake of cadmium as109Cd‐cysteine was greater and that of109Cd‐metallothionein lower compared with that of the other substances. These observations were made on non‐pretreated cells. In cells taken from rats pretreated with CdCl2in vivo, the uptake of cadmium as109CdCl2,109Cd‐cysteine and109Cd‐albumin was lower than in cells from non‐pretreated rats. However, the uptake of109Cd‐metallothionein was considerably enhanced in pretreated cells. In pretreated kidney cells the decreased uptake of Cd (as Cd‐albumin) might be related to protection of the kidney against acute Cd toxicity and increased uptake of metallothionein‐Cd might contribute to the explanation of renal damage
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