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首页> 外文期刊>british journal of haematology >The combination of erythropoietin and granulocyte colony‐stimulating factor increases the rate of haemopoietic recovery with clinical benefit after peripheral blood progenitor cell transplantation
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The combination of erythropoietin and granulocyte colony‐stimulating factor increases the rate of haemopoietic recovery with clinical benefit after peripheral blood progenitor cell transplantation

机译：The combination of erythropoietin and granulocyte colony‐stimulating factor increases the rate of haemopoietic recovery with clinical benefit after peripheral blood progenitor cell transplantation

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In order to investigate the effects of erythropoietin (EPO) plus granulocyte colony‐stimulating factor (G‐CSF) administration after peripheral blood progenitor cell transplantation (PBPCT) we performed a phase I/II study in patients with high‐risk cancer. 15 consecutive patients were treated with recombinant human G‐CSF (rhG‐CSF) at the dose of 5 μg/kg subcutaneously (s.c.) every 24 h until day +12 and with recombinant human EPO (rhEPO) at the dose of 150 IU/kg s.c. every 48 h until day +11 following PBPCT. Their haemopoietic recovery was compared to that obtained in eight historic control patients who did not receive any cytokines after PBPCT. No side‐effects were observed during EPO plus G‐CSF treatment and the treatment was not discontinued in any of the patients before completion of the treatment plan. The administration of EPO plus G‐CSF after PBPCT produced a significant increase in the rate of white blood cell (WBC) (P = 0.0005), polymorphonuclear leucocyte (PMN) (P = 0.0005) and platelet (PLT) (P = 0.0105) recovery compared to the control group. The acceleration in haemopoietic recovery observed in the EPO plus G‐CSF‐treated patients produced a significant reduction of the days with WBC 38°C for a median period of 4 d (0–12) with a median period of parenteral antibiotic administration of 7.5 d (0–17). The length of the hospital stay was significantly shorter in the study group than in the historic control group (P = 0.0264). In conclusion, we can confirm that EPO plus G‐CSF treatment is feasible and potentiates the haemopoietic recovery after PBPCT, thus s

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