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>Sensitivity to two major allergens (Cry jI andCry jII) in patients with Japanese cedar (Cryptomeria japonica) pollinosis
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Sensitivity to two major allergens (Cry jI andCry jII) in patients with Japanese cedar (Cryptomeria japonica) pollinosis
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机译：Sensitivity to two major allergens (Cry jI andCry jII) in patients with Japanese cedar (Cryptomeria japonica) pollinosis
SummaryBackground:Japanese cedar (Cryptmeria japonica: CJ) pollinosis is one of the most important allergic diseases in Japan. Recently, the second major allergen (Cry jII) was isolated from CJ pollen. There have been no prevalence studies of sensitivity toCry jI andCry jII among a large number of patients with pollinosis.Objective:This study was conducted to evaluate the prevalence of sensitivity toCry jI andCry jII. We measured specific IgE antibodies to these allergens in the sera of 145 patients. Furthermore, comparison of the sensitivity toCry jI andCry jII was examined by the hisiamine release assay.Methods:Specific IgE antibodies toCry jI andCry jII were assayed by a fluorometric ELISA. Allergen‐specific histamine release was measured by a radioimmunoassay kit,Results:More than 90 of 145 patients had specific IgE antibodies to both allergens. the remainder had specific IgE to either one or the other. There were seasonal changes in the level of specific IgE. The changes in the levels of anti‐Cry jII IgE antibodies were parallel to those of anti‐Cry jI IgE. The histamine release assay with leucocytes from the patients demonstrated that the allergenic potency of the two allergens is almost the same.Conclusion:Cry jII is an as important a major allergen asC
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