Psychophysiological Investigation of Combat Veterans with Subthreshold Post-traumatic Stress Disorder Symptoms

Costanzo Michelle; Jovanovic Tanja; Norrholm Seth D.Ndiongue RochelleReinhardt BrianRoy Michael J.

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Psychophysiological Investigation of Combat Veterans with Subthreshold Post-traumatic Stress Disorder Symptoms

机译：Psychophysiological Investigation of Combat Veterans with Subthreshold Post-traumatic Stress Disorder Symptoms

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Objective: Military service members (SMs) with subthreshold combat-related post-traumatic stress disorder (PTSD) symptoms often have clinically significant functional impairment, even though they do not meet full PTSD criteria. We therefore assessed the psychophysical responses of SMs, upon their return from Afghanistan or Iraq, to a fear conditioning paradigm to better understand the biological underpinnings of symptom severity. Methods: Heart rate (HR), skin conductance, electromyography startle, and respiratory rate (RR) were monitored throughout three distinct phases of the paradigm-fear acquisition, fear inhibition, and fear extinction-while plasma catecholamines (epinephrine, norepinephrine, and dopamine) were measured at the end of fear inhibition. Results: Those with higher PTSD symptom severity demonstrated elevations in HR and startle response to danger cues; elevated self-reported depression and anxiety; impaired functional status; poor skin conductance discrimination between danger and safety; and increases in HR and RR during fear extinction. Moreover, an inverse relationship was seen between plasma dopamine and HR during fear inhibition for those with high symptoms. Conclusion: Overall, the physiological responses we observed in our subthreshold PTSD population parallel what has been previously observed in full PTSD, making a case for addressing subthreshold PTSD symptoms in combat veterans.

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《Military Medicine: Official Journal of AMSUS, The Society of the Federal Health Agencies》 |2016年第8期|793-802|共10页
作者
Costanzo Michelle; Jovanovic Tanja; Norrholm Seth D.Ndiongue RochelleReinhardt BrianRoy Michael J.;
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Uniformed Serv Univ Hlth Sci, Dept Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA;

Emory Univ, Sch Med, Dept Psychiat & Behav Sci, 201 Dowman Dr, Atlanta, GA 30322 USA;

Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, 8901 Rockville Pike, Bethesda, MD 20889Walter Reed Natl Mil Med Ctr, Dept Res Programs, 8901 Rockville Pike, Bethesda, MD 20889 USA;

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正文语种英语
中图分类军事医学;
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Psychophysiological Investigation of Combat Veterans with Subthreshold Post-traumatic Stress Disorder Symptoms

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