Maintenance of Intermediolateral Spinal Cord Neurons by Fibroblast Growth Factor Administered to the Medullectomized Rat Adrenal Gland: Dependence on Intact Adrenal Innervation and Cellular Organization of Implants

Dieter Blottner; Klaus Unsicker

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Maintenance of Intermediolateral Spinal Cord Neurons by Fibroblast Growth Factor Administered to the Medullectomized Rat Adrenal Gland: Dependence on Intact Adrenal Innervation and Cellular Organization of Implants

机译：Maintenance of Intermediolateral Spinal Cord Neurons by Fibroblast Growth Factor Administered to the Medullectomized Rat Adrenal Gland: Dependence on Intact Adrenal Innervation and Cellular Organization of Implants

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AbstractWe have previously shown that basic fibroblast growth factor (bFGF; 2 μg), when administered in gelfoams implanted to medullectomized adult rat adrenal glands, maintains target‐deprived preganglionic neurons located in the intermediolateral column (IML) of the spinal cord. We show now that administration of 600 or 60 ng/implant/organ of the biologically active recombinant protein also maintains IML‐neurons. The effects depend on an intact organ nerve supply since administration of bFGF‐implants to the medullectomized and denervated (splanchnicotomized) organ abolishes the maintenance effects for IML‐neurons. A possible regeneration of cholinergic nerve fibres was assessed by quantitative determination of choline acetyltransferase (ChAT)‐activity and ultrastructurally under various treatments. When compared to a cytochrome‐(Cyto)‐C treatment, bFGF significantly increased ChAT‐activity in the innervated adrenal gland after 4 weeks, suggesting that sprouting of cholinergic nerve fibres and/or recovery of enzyme activity had occurred. Electron microscopically, unmyelinated axons associated with Schwann cells were only found in bFGF, but not in Cyto‐C‐implants. We conclude that exogenous bFGF or a yet unidentified trophic molecule possibly induced by bFGF in the adrenal gland acts as a retrogradely transported messenger serving for the maintenance of spinal cord IML‐neuronsin vivo. By stimulating axonal sprouting, bFGF might facilitate access of trophic ma

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《european journal of neuroscience》 |1990年第4期|378-382|共页
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Dieter Blottner; Klaus Unsicker;
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正文语种英语
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fibroblast growth factor; central nervous system; peripheral nervous system; adrenal innervation; choline acetyltransferase; axotomy; rat;

Maintenance of Intermediolateral Spinal Cord Neurons by Fibroblast Growth Factor Administered to the Medullectomized Rat Adrenal Gland: Dependence on Intact Adrenal Innervation and Cellular Organization of Implants

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