...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>european journal of neuroscience >A Decrease in Ca2+cbut not in cAMP Mediates L‐AP4 Inhibition of Glutamate Release: PKC‐mediated Suppression of this Inhibitory Pathway
【24h】

A Decrease in Ca2+cbut not in cAMP Mediates L‐AP4 Inhibition of Glutamate Release: PKC‐mediated Suppression of this Inhibitory Pathway

机译：A Decrease in Ca2+cbut not in cAMP Mediates L‐AP4 Inhibition of Glutamate Release: PKC‐mediated Suppression of this Inhibitory Pathway

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

AbstractWe investigated the mechanism of the inhibition of glutamate release by L‐2‐amino‐4‐phosphonobutyrate (L‐AP4) in cerebrocortical nerve terminals from young rats (3 weeks of age). The Ca2+‐dependent release of glutamate was reduced by L‐AP4 in a concentration‐dependent manner. This inhibitory effect was prevented by pertussis toxin, insensitive to staurosporine and associated with a reduction both in the depolarization‐evoked increase in the cytoplasmic free Ca2+concentration (Ca2+c) and in forskolin‐stimulated cAMP formation. However, the reduction in Ca2+cbut not in cAMP seemed to be responsible for the decrease in release, since inhibition by L‐AP4 can also be observed in the absence of detectable changes in CAMP. The inhibitory modulation by L‐AP4 was suppressed by the activation of protein kinase C with phorbol esters. The nerve terminals from young rats also exhibited a facilitatory pathway of glutamate release which was mediated by protein kinase C. Interestingly, stimulation of this pathway with the glutamate agonist (1 S,3R)‐1‐aminocyclopentane‐1,3‐dicarboxylate in the presence of arachidonic acid also abolished the inhibitory action of L‐AP4. The dominance of the facilitatory pathway in its interaction with the L‐AP4‐mediated inhibitory control may provide some clues to understand the presynapt

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号