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外文期刊>british journal of haematology
>Increased serum CD8 soluble antigen level is associated with blood lymphocyte abnormalities and other established indicators of a poor prognosis in adult Hodgkin's disease
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Increased serum CD8 soluble antigen level is associated with blood lymphocyte abnormalities and other established indicators of a poor prognosis in adult Hodgkin's disease
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机译：Increased serum CD8 soluble antigen level is associated with blood lymphocyte abnormalities and other established indicators of a poor prognosis in adult Hodgkin's disease
Summary.Measurement of the soluble form of CD8 antigen (sCD8), a surface membrane component of suppressor/cytotoxic T cells, has yielded useful information relevant to prognosis in children with acute lymphoblastic leukaemia and Hodgkin's disease (HD). An ELISA technique was used to measure the amount of sCD8 in sera from 123 adults with untreated HD. Significantly higher mean sCD8 levels were found in patients with advanced disease (stage III‐IV;P<0·001), B‐symptoms (P<0·001), male sex (P<0·05) and increased spontaneous and decreased Concanavalin A induced blood lymphocyte DNA‐synthesis (P<0·05). Actuarial survival of patients with high sCD8 levels was significantly worse than that of the remainder (P<0·05). However, the sCD8 level did not add prognostic information to that achieved by age, sex, lactate dehydrogenase (LDH) or clinical stage. A significant correlation between the sCD8 and LDH levels (r= 0·33;P<0·001) and inverse correlations between sCD8 levels and total blood CD4+(r= −0·52;P<0·001) and CD3+(r= −0·39;P<0·01) cell counts were found. Ten patients were also studied in complete remission, showing a significantly reduced sCD8 level in comparison to the pretreatment value (P<0·05). Increased sCD8 in HD may indicate enhanced suppressor T cell activity possibly compromising the host disease balance which could explain the assoc
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