A comparison of preoperative serum tumor markers (lactate dehydrogenase, lactate dehydrogenase isoenzymes, alpha;-hydroxybutyrate dehydrogenase, alkaline phosphatase, aldolase, Ieucine aminopeptidase, cholinesterase, erythrocyte sedimentation reaction, carcinoembryonic antigen, alpha;-fetoprotein, and beta;2-microglobulin) was made in 76 patients with ovarian or uterine cancer. Sixty-six patients with benign ovarian tumor served as control subjects. From analysis of each tumor marker the greatest positive results were obtained with the markers beta;2-microglobulin (57.1percnt;), lactate dehydrogenase (53.1percnt;), and hydroxybutyrate dehydrogenase (46.2percnt;) for patients with carcinoma of the ovary. The use of these marker combinations in all ovarian cancer patients resulted in a marked increase of the positive rate from 57.1 to 85.2percnt;. In stage I cases, the positive rate increased from 40.6 to 63.6percnt;.
展开▼
