Specialized stem cell niche enables repetitive renewal of alligator teeth

Wu P.; Wu X.; Jiang T.-X.Elsey R.M.Temple B.L.Divers S.J.Glenn T.C.Yuan K.Chen M.-H.Widelitz R.B.Chuong C.-M.

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Specialized stem cell niche enables repetitive renewal of alligator teeth

机译：Specialized stem cell niche enables repetitive renewal of alligator teeth

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Reptiles and fish have robust regenerative powers for tooth renewal. However, extant mammals can either renew their teeth one time (diphyodont dentition) or not at all (monophyodont dentition). Humans replace their milk teeth with permanent teeth and then lose their ability for tooth renewal. Here, we study tooth renewal in a crocodilian model, the American alligator, which has well-organized teeth similar to mammals but can still undergo life-long renewal. Each alligator tooth is a complex family unit composed of the functional tooth, successional tooth, and dental lamina. Using multiple mitotic labeling,wemap putative stemcells to the distal enlarged bulge of the dental lamina that contains quiescent odontogenic progenitors that can be activated during physiological exfoliation or artificial extraction. Tooth cycle initiation correlates with ?-catenin activation and soluble frizzled-related protein 1 disappearance in the bulge. The dermal niche adjacent to the dermal lamina dynamically expresses neural cell adhesion molecule, tenascin-C, and other molecules. Furthermore, in development, asymmetric ?-catenin localization leads to the formation of a heterochronous and complex tooth family unit configuration. Understanding how these signaling molecules interact in tooth development in this model may help us to learn how to stimulate growth of adult teeth in mammals.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第22期|E2009-E2018|共10页
作者
Wu P.; Wu X.; Jiang T.-X.Elsey R.M.Temple B.L.Divers S.J.Glenn T.C.Yuan K.Chen M.-H.Widelitz R.B.Chuong C.-M.;
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作者单位

Department of Pathology, University of Southern California, Los Angeles, CA 90033, United States;

Louisiana Department of Wildlife and Fisheries, Rockefeller Wildlife Refuge, Grand Chenier, LA 70643, United States;

Environmental Health Science, United StatesDepartment of Small Animal Medicine and Surgery, University of Georgia, Athens, GA 30602, United StatesDepartment of Dentistry, United StatesResearch Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan City 70101, Taiwan;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Placode; Regeneration; Slow Cycling; Wnt;

Specialized stem cell niche enables repetitive renewal of alligator teeth

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