...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America. >Beyond the classical thermodynamic contributions to hydrogen atom abstraction reactivity
【24h】

Beyond the classical thermodynamic contributions to hydrogen atom abstraction reactivity

机译：Beyond the classical thermodynamic contributions to hydrogen atom abstraction reactivity

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Hydrogen atom abstraction (HAA) reactions are cornerstones of chemistry. Various (metallo)enzymes performing the HAA catalysis evolved in nature and inspired the rational development of multiple synthetic catalysts. Still, the factors determining their catalytic efficiency are not fully understood. Herein, we define the simple thermodynamic factor eta by employing two thermodynamic cycles: one for an oxidant (catalyst), along with its reduced, protonated, and hydrogenated form; and one for the substrate, along with its oxidized, deprotonated, and dehydrogenated form. It is demonstrated that eta reflects the propensity of the substrate and catalyst for (a)synchronicity in concerted H+/e(-) transfers. As such, it significantly contributes to the activation energies of the HAA reactions, in addition to a classical thermodynamic (Bell-EvansPolanyi) effect. In an attempt to understand the physicochemical interpretation of eta, we discovered an elegant link between vertical bar eta vertical bar and reorganization energy lambda, from Marcus theory. We discovered computationally that for a homologous set of HAA reactions, lambda, reaches its maximum for the lowest eta, which then corresponds to the most synchronous HAA mechanism. This immediately implies that among HAA processes with the same reaction free energy, Delta G(0), the highest barrier (Delta G not equal) is expected for the most synchronous proton-coupled electron (i.e., hydrogen) transfer. As proof of concept, redox and acidobasic properties of nonheme Fe-IV O complexes are correlated with activation free energies for HAA from C-H and O-H bonds. We believe that the reported findings may represent a powerful concept in designing new HAA catalysts.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号