Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation

Wang Weicang; Yang Jun; Zhang JiananWang YuxinHwang Sung HeeQi WeipengWan DebinKim DaeyoungSun JiaSanidad Katherine Z.Yang HaixiaPark YeonhwaLiu Jun-YanZhao XinfengZheng XiaohuiLiu ZhenhuaHammock Bruce D.Zhang Guodong

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America. >Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation

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Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation

机译：Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation

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Obesity is associated with enhanced colonic inflammation, which is a major risk factor for colorectal cancer. Considering the obesity epidemic in Western countries, it is important to identify novel therapeutic targets for obesity-induced colonic inflammation, to develop targeted strategies for prevention. Eicosanoids are endogenous lipid signaling molecules involved in regulating inflammation and immune responses. Using an LC-MS/MS-based lipidomics approach, we find that obesity-induced colonic inflammation is associated with increased expression of soluble epoxide hydrolase (sEH) and its eicosanoid metabolites, termed fatty acid diols, in colon tissue. Furthermore, we find that pharmacological inhibition or genetic ablation of sEH reduces colonic concentrations of fatty acid diols, attenuates obesity-induced colonic inflammation, and decreases obesity-induced activation of Wnt signaling in mice. Together, these results support that sEH could be a novel therapeutic target for obesity-induced colonic inflammation and associated diseases.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2018年第20期|5283-5288|共6页
作者
Wang Weicang; Yang Jun; Zhang JiananWang YuxinHwang Sung HeeQi WeipengWan DebinKim DaeyoungSun JiaSanidad Katherine Z.Yang HaixiaPark YeonhwaLiu Jun-YanZhao XinfengZheng XiaohuiLiu ZhenhuaHammock Bruce D.Zhang Guodong;
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作者单位

Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA;

Univ Calif Davis, Dept Entomol & Nematol, Davis, CA 95616 USA;

Univ Massachusetts, Dept Math & Stat, Amherst, MA 01003 USATongji Univ, Sch Med, Shanghai Peoples Hosp 10, Ctr Nephrol & Metabol, Shanghai 210072, Peoples R ChinaNorthwest Univ, Coll Life Sci, Xian 710069, Shaanxi, Peoples R ChinaUniv Massachusetts, Mol & Cellular Biol Grad Program, Amherst, MA 01003 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
obesity; colonic inflammation; soluble epoxide hydrolase;

Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation

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