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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Contribution of a mutational hot spot to hemoglobin adaptation in high-altitude Andean house wrens
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Contribution of a mutational hot spot to hemoglobin adaptation in high-altitude Andean house wrens

机译：Contribution of a mutational hot spot to hemoglobin adaptation in high-altitude Andean house wrens

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A key question in evolutionary genetics is why certain mutations or certain types of mutation make disproportionate contributions to adaptive phenotypic evolution. In principle, the preferential fixation of particular mutations could stem directly from variation in the underlying rate of mutation to function-altering alleles. However, the influence of mutation bias on the genetic architecture of phenotypic evolution is difficult to evaluate because data on rates of mutation to function-altering alleles are seldom available. Here, we report the discovery that a single point mutation at a highly mutable site in the beta(A)-globin gene has contributed to an evolutionary change in hemoglobin (Hb) function in high-altitude Andean house wrens (Troglodytes aedon). Results of experiments on native Hb variants and engineered, recombinant Hb mutants demonstrate that a nonsynonymous mutation at a CpG dinucleotide in the beta(A)-globin gene is responsible for an evolved difference in Hb-O-2 affinity between high-and low-altitude house wren populations. Moreover, patterns of genomic differentiation between high-and low-altitude populations suggest that altitudinal differentiation in allele frequencies at the causal amino acid polymorphism reflects a history of spatially varying selection. The experimental results highlight the influence of mutation rate on the genetic basis of phenotypic evolution by demonstrating that a large-effect allele at a highly mutable CpG site has promoted physiological differentiation in blood O-2 transport capacity between house wren populations that are native to different elevations.

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