Temporal control over the initiation of cell motility by a regulator of G-protein signaling

Johannes Hartwig; Katsiaryna Tarbashevich; Jochen Seggewi?Martin StehlingJan BandemerCecilia GrimaldiAzadeh PaksaTheresa Gro?-ThebingDana MeyenErez Raz

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Temporal control over the initiation of cell motility by a regulator of G-protein signaling

机译：Temporal control over the initiation of cell motility by a regulator of G-protein signaling

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摘要

The control over the acquisition of cellmotility is central for a variety of biological processes in development, homeostasis, and disease. An attractive in vivo model for investigating the regulation of migration initiation is that of primordial germ cells (PGCs) in zebrafish embryos. In this study, we show that, following PGC specification, the cells can polarize but do not migrate before the time chemokine-encoded directional cues are established.Wefound that the regulator of G-protein signaling 14a protein, whose RNA is a newly identified germ plasm component, regulates the temporal relations between the appearance of the guidance molecules and the acquisition of cellular motility by regulating E-cadherin levels.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第31期|11389-11394|共6页
作者
Johannes Hartwig; Katsiaryna Tarbashevich; Jochen Seggewi?Martin StehlingJan BandemerCecilia GrimaldiAzadeh PaksaTheresa Gro?-ThebingDana MeyenErez Raz;
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作者单位

Institute for Cell Biology, Center for Molecular Biology of Inflammation, Münster University, D-48149 Münster, Germany;

Integrated Functional Genomics, Interdisciplinary Center for Clinical Research, Münster University, D-48149 Münster, Germany;

Flow Cytometry Unit, Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
rgs protein; cell adhesion;

Temporal control over the initiation of cell motility by a regulator of G-protein signaling

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