Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade

Wang Feng; Yin Qian; Chen LiangDavis Mark M.

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Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade

机译：Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade

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Antibodies that attenuate immune tolerance have been used to effectively treat cancer, but they can also trigger severe autoimmunity. To investigate this, we combined anti-CTLA-4 treatment with a standard colitis model to give mice a more severe form of the disease. Pretreatment with an antibiotic, vancomycin, provoked an even more severe, largely fatal form, suggesting that a Gram-positive component of the microbiota had a mitigating effect. We then found that a commonly used probiotic, Bifidobacterium, could largely rescue the mice from immunopathology without an apparent effect on antitumor immunity, and this effect may be dependent on regulatory T cells.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2018年第1期|157-161|共5页
作者
Wang Feng; Yin Qian; Chen LiangDavis Mark M.;
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作者单位

Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Ctr Microbiota & Immunol Dis,Shanghai Gen Hosp, Shanghai 200025, Peoples R China;

Stanford Univ, Sch Med, Inst Immun Transplantat & Infect, Stanford, CA 94305 USA;

Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
probiotics; Bifidobacterium; CTLA-4; immune checkpoint blockade; intestinal immunopathology;

Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade

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