SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems

Brendan N. Lilley; Arjun Krishnaswamy; Zhi WangMasashi KishiEric FrankJoshua R. Sanes

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SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems

机译：SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems

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Axons develop in a series of steps, beginning with specification, outgrowth, and arborization, and terminating with formation and maturation of presynaptic specializations. We found previously that the SAD-A and SAD-B kinases are required for axon specification and arborization in subsets of mouse neurons. Here, we show that following these steps, SAD kinases become localized to synaptic sites and are required within presynaptic cells for structural and functional maturation of synapses in both peripheral and central nervous systems. Deleting SADs from sensory neurons can perturb either axonal arborization or nerve terminal maturation, depending on the stage of deletion. Thus, a single pair of kinases plays multiple, sequential roles in axonal differentiation.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第3期|1138-1143|共6页
作者
Brendan N. Lilley; Arjun Krishnaswamy; Zhi WangMasashi KishiEric FrankJoshua R. Sanes;
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作者单位

Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138;

Department of Physiology, Tufts University School of Medicine, Boston, MA 02115;

Laboratory of Molecular Neuroimaging, Niigata University Graduate School of Medical and Dental Sciences, Nigata 951-8510, Japan;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
neuromuscular junction; sympathetic ganglion; spinal cord; Ia synapse; Calyx of Held;

SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems

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