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>Studies on the applicability of biomarkers in estimating the systemic bioavailability of polynuclear aromatic hydrocarbons from manufactured gas plant tar-contaminated soils
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Studies on the applicability of biomarkers in estimating the systemic bioavailability of polynuclear aromatic hydrocarbons from manufactured gas plant tar-contaminated soils
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机译：Studies on the applicability of biomarkers in estimating the systemic bioavailability of polynuclear aromatic hydrocarbons from manufactured gas plant tar-contaminated soils
The systemic bioavailability of polynuclear aromatic hydrocarbons (PAH) from ingested soils containing manufactured gas plant (MGP) tar was evaluated in mice. Soil and organic extract of each soil were incorporated into a diet and fed to mice fortwo weeks. 1-Hydroxypyrene levels in urine and chemical: DNA adduct levels in lungs were used as biomarkers of PAH systemic bioavailability. Estimates of PAH relative bioavailability were determined by comparing the bioavailability observed between eachsoil and corresponding organic extract. In all but one case, bioavailability estimates based on 1-hydroxypyrene levels in urine indicate that the presence of MGP tar on soil results in a considerable decrease in PAH systemic bioavailability (9-75).Similarly, PAH bioavailability estimates based on chemical: DNA adduct formation ranged from nondetectable to 76. These results clearly indicate that the bioavailability of PAH is less than 100 when soil contaminated with MGP tar is ingested by mice. In addition, the experimental methods employed in this study appear suitable for evaluating the effects of soil on the gastrointestinal absorption and systemic bioavailability of PAH from soil containing complex organic mixtures.
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