Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus

Deng L.; Zhong L.; Struble E.Duan H.Li M.Harman C.Yan H.Virata-Theimer M.L.Zhao Z.Feinstone S.Alter H.Zhang P.

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus

【24h】

Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus

机译：Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Hepatitis C virus (HCV) envelope glycoprotein E2 has been considered as a major target for vaccine design. Epitope II, mapped between residues 427-446 within the E2 protein, elicits antibodies that are either neutralizing or nonneutralizing. The fundamental mechanism of antibody-mediated neutralization at epitope II remains to be defined at the atomic level. Here we report the crystal structure of the epitope II peptide in complex with a monoclonal antibody (mAb#8) capable of neutralizing HCV. The complex structure revealed that this neutralizing antibody engages epitope II via interactions with both the C-terminal α-helix and the N-terminal loop using a bifurcated mode of action. Our structural insights into the key determinants for the antibody-mediated neutralization may contribute to the immune prophylaxis of HCV infection and the development of an effective HCV vaccine.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第18期|7418-7422|共5页
作者
Deng L.; Zhong L.; Struble E.Duan H.Li M.Harman C.Yan H.Virata-Theimer M.L.Zhao Z.Feinstone S.Alter H.Zhang P.;
展开▼
作者单位

Division of Hematology, Office of Blood Research and Review, Food and Drug Administration, Bethesda, MD 20892, United States;

Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States;

Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, United States;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词

Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus

摘要

著录项

相关主题

期刊订阅