Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen

Speiser DE; Baurngaertner P; Voelter VDevevre EBarbey CRufer NRomero P

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen

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Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen

机译：Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen

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摘要

Human cancer vaccines are often prepared with altered "analog" or "heteroclitic" antigens that have been optimized for HLA class I binding, resulting in enhanced immunogenicity. Here, we take advantage of CpG oligodeoxynucleotides as powerful vaccine adjuvants and demonstrate the induction of high T cell frequencies in melanoma patients, despite the use of natural (unmodified) tumor antigenic peptide. Compared with vaccination with analog peptide, natural peptide induced T cell frequencies that were approximately twofold lower. However, T cells showed superior tumor reactivity because of (i) increased functional avidity for natural antigen and (it) enhancement of T cell activation and effector function. Thus, novel vaccine formulations comprising potent immune stimulators may allow to circumvent the need for modified antigens and can induce highly functional T cells with precise antigen specificity.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第10期|3849-3854|共6页
作者
Speiser DE; Baurngaertner P; Voelter VDevevre EBarbey CRufer NRomero P;
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作者单位

Ludwig Inst Canc Res, Div Clin Oncoimmunol, CH-1001 Lausanne, Switzerland.;

CHU Vaudois, Multidisciplinary Oncol Ctr, CH-1001 Lausanne, Switzerland.;

Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
analog peptides; CD8 T cell specificity; CpG oligodeoxynucleotides; immunotherapy; Toll-like receptor 9;

Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen

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