Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

Md. Hasan Zaki; Si Ming Man; Peter VogelMohamed LamkanfiThirumala-Devi Kanneganti

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Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

机译：Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

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The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 12 (NLRP12) plays a protective role in intestinal inflammation and carcinogenesis, but the physiological function of this NLR during microbial infection is largely unexplored. Salmonella enterica serovar Typhimurium (S. typhimurium) is a leading cause of food poisoning worldwide. Here, we show that NLRP12-deficient mice were highly resistant to S. typhimurium infection. Salmonella-infected macrophages induced NLRP12-dependent inhibition of NF-κB and ERK activation by suppressing phosphorylation of IκBα and ERK. NLRP12-mediated down-regulation of proinflammatory and antimicrobial molecules prevented efficient clearance of bacterial burden, highlighting a role for NLRP12 as a negative regulator of innate immune signaling during salmonellosis. These results underscore a signaling pathway defined by NLRP12-mediated dampening of host immune defenses that could be exploited by S. typhimurium to persist and survive in the host.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第1期|385-390|共6页
作者
Md. Hasan Zaki; Si Ming Man; Peter VogelMohamed LamkanfiThirumala-Devi Kanneganti;
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作者单位

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105;

Animal Resources Center and the Veterinary Pathology Core, St. Jude Children's Research Hospital, Memphis, TN 38105;

Department of Medical Protein Research, Vlaams Instituut voor Biotechnologie, B-9000 Ghent, Belgium;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Salmonella; immune; infection;

Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

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