Controlled fire use in early humans might have triggered the evolutionary emergence of tuberculosis

Chisholm Rebecca H.; Trauer James M.; Curnoe DarrenTanaka Mark M.

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Controlled fire use in early humans might have triggered the evolutionary emergence of tuberculosis

机译：Controlled fire use in early humans might have triggered the evolutionary emergence of tuberculosis

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Tuberculosis (TB) is caused by the Mycobacterium tuberculosis complex (MTBC), a wildly successful group of organisms and the leading cause of death resulting from a single bacterial pathogen worldwide. It is generally accepted that MTBC established itself in human populations in Africa and that animal-infecting strains diverged from human strains. However, the precise causal factors of TB emergence remain unknown. Here, we propose that the advent of controlled fire use in early humans created the ideal conditions for the emergence of TB as a transmissible disease. This hypothesis is supported by mathematical modeling together with a synthesis of evidence from epidemiology, evolutionary genetics, and paleoanthropology.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2016年第32期|9051-9056|共6页
作者
Chisholm Rebecca H.; Trauer James M.; Curnoe DarrenTanaka Mark M.;
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作者单位

Univ New South Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia;

Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic 3004, Australia;

Univ New South Wales, Palaeontol Geobiol & Earth Arch Res Ctr, Sydney, NSW 2052, Australia;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
tuberculosis; pathogen evolution; cultural evolution; epidemiology; mathematical modeling;

Controlled fire use in early humans might have triggered the evolutionary emergence of tuberculosis

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