Dipeptides promote folding and peptide binding of MHC class i molecules

Saini S.K.; Ostermeir K.; Ramnarayan V.R.Schuster H.Zacharias M.Springer S.

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Dipeptides promote folding and peptide binding of MHC class i molecules

机译：Dipeptides promote folding and peptide binding of MHC class i molecules

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摘要

MHC class I molecules bind only those peptides with high affinity that conform to stringent length and sequence requirements. We have now investigated which peptides can aid the in vitro folding of class I molecules, and we find that the dipeptide glycyl-leucine efficiently supports the folding of HLA-A*02:01 and H-2K~b into a peptide-receptive conformation that rapidly binds high-affinity peptides. Treatment of cells with glycyl-leucine induces accumulation of peptide-receptive H-2K~b and HLA-A*02:01 at the surface of cells. Other dipeptides with a hydrophobic second amino acid show similar enhancement effects. Our data suggest that the dipeptides bind into the F pocket like the C-terminal amino acids of a highaffinity peptide. antigen presentation ligand exchange chemical chaperones endoplasmic reticulum quality control.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第38期|15383-15388|共6页
作者
Saini S.K.; Ostermeir K.; Ramnarayan V.R.Schuster H.Zacharias M.Springer S.;
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作者单位

Molecular Life Science Center, Jacobs University Bremen, 28759 Bremen, Germany;

Physics Department T38, Technical University Munich, 85748 Garching, Germany;

Department of Immunology, Tübingen University, 72076 Tübingen, Germany;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Dipeptides; peptide; binding;

Dipeptides promote folding and peptide binding of MHC class i molecules

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