Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice

Seung Eun Lee; Jaekwang Lee; Charles LatchoumaneBoyoung LeeSoo-Jin OhZahangir Alam SaudCheongdahm ParkNing SunEunji CheongChien-Chang ChenEui-Ju ChoiC. Justin LeeHee-Sup Shin

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Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice

机译：Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice

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Intrinsic burst and rhythmic burst discharges (RBDs) are elicited by activation of T-type Ca~(2+) channels in the thalamic reticular nucleus (TRN). TRN bursts are believed to be critical for generation and maintenance of thalamocortical oscillations, leading to the spikeand-wave discharges (SWDs), which are the hallmarks of absence seizures. We observed that the RBDs were completely abolished, whereas tonic firing was significantly increased, in TRN neurons from mice in which the gene for the T-type Ca~(2+) channel, CaV3.3, was deleted (CaV3.3~(-/-)). Contrary to expectations, there was an increased susceptibility to drug-induced SWDs both in CaV3.3~(-/-) mice and in mice in which the CaV3.3 gene was silenced predominantly in the TRN. CaV3.3~(-/-) mice also showed enhanced inhibitory synaptic drive onto TC neurons. Finally, a double knockout of both CaV3.3 and CaV3.2, which showed complete elimination of burst firing and RBDs in TRN neurons, also displayed enhanced drug-induced SWDs and absence seizures. On the other hand, tonic firing in the TRN was increased in these mice, suggesting that increased tonic firing in the TRN may be sufficient for druginduced SWD generation in the absence of burst firing. These results call into question the role of burst firing in TRN neurons in the genesis of SWDs, calling for a rethinking of the mechanism for absence seizure induction.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第32期|11828-11833|共6页
作者
Seung Eun Lee; Jaekwang Lee; Charles LatchoumaneBoyoung LeeSoo-Jin OhZahangir Alam SaudCheongdahm ParkNing SunEunji CheongChien-Chang ChenEui-Ju ChoiC. Justin LeeHee-Sup Shin;
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作者单位

Center for Cognition and Sociality, Institute for Basic Science, Daejeon 305-811, Korea;

Center for Neural Science, Brain Science Institute, Korea Institute of Science and Technology, Seoul 136-791, Korea;

Department of Protein Sciences, Amgen, Inc., Thousand Oaks, CA 91320Department of Biotechnology, College of Life Science and Biotechnology, Translational Research Center for Protein Function Control, Yonsei University, Seoul 120-749, KoreaInstitute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 115, TaiwanLaboratory of Cell Death and Human Diseases, Department of Life Sciences, School of Life Sciences, Korea University, Seoul 136-701, KoreaCenter for Functional Connectomics, Brain Science Institute, Korea Institute of Science and Technology, Seoul 136-791, Korea;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
reticular thalamus; pharmacological absence; mice;

Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice

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