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首页> 外文期刊>International immunopharmacology >Inactivation of cadmium induced immunotoxicological alterations in rats by Tunisian montmorillonite clay.
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Inactivation of cadmium induced immunotoxicological alterations in rats by Tunisian montmorillonite clay.

机译：突尼斯蒙脱土粘土灭活镉诱导的大鼠免疫毒理学改变。

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摘要

Cadmium (Cd(2+)) is a heavy metal that is dispersed throughout the modern environment mainly as a result of pollution from a variety of sources. The aims of the current study were to investigate the efficacy of purified Tunisian montmorillonite clay (TMC) to adsorb Cd, to test the stability of the resulting complex under different conditions in vitro, and to utilize the rat bioassay as an in vivo model to evaluate the protective role of TMC against Cd-induced toxicity and immunodysfunction. In the in vitro study, three concentrations of TMC (0.5, 1.0 and 1.5 g/l aqueous solution) and three concentrations of CdCl(2) (25, 50 and 100 ppm) were tested. The results of the in vitro study showed that TMC had a high capacity of adsorbing Cd at different concentrations tested. The adsorption ranged from 95.7-100% of the available CdCl(2) in aqueous solutions. The complex TMC-Cd was stable at different pHs at 37 degrees C. The in vivo results indicated that treatment with CdCl(2) (2.5 mg/kg BW) for 2 weeks resulted in a significant decrease in triglycerides, total protein, creatinine, creatine kinase, immunoglobulin profile (Ig A and Ig G) and T-cell sub-types (CD3(+), CD4(+), CD8(+) and CD56(+)). Whereas, it significantly increase serum level of AST, ALT, LDH and induced degenerative changes in pro-inflammatory cytokines (TNF-alpha and IL-1). Rats treated with TMC alone (400, 600 and 800 mg/kg BW) were comparable to the control regarding all the tested parameters. The combined treatment of CdCl(2) and TMC at the lowest dose (400 mg/kg BW) showed a significant improvement of all tested parameters. It could be concluded that TMC was effective to protect against Cd hazards at a dose as low as 400 mg/kg BW. These results supported our hypothesis that TMC tightly-bind and immobilized Cd resulted in reduction of metal bioavailability in the gastrointestinal tract.
机译：镉（Cd（2+））是一种重金属，主要由于各种来源的污染而散布在整个现代环境中。本研究的目的是研究纯化的突尼斯蒙脱石粘土（TMC）吸附Cd的功效，在不同条件下体外测试所得复合物的稳定性，并利用大鼠生物测定作为体内模型来评估TMC对镉诱导的毒性和免疫功能障碍的保护作用。在体外研究中，测试了三种浓度的TMC（0.5、1.0和1.5 g / l水溶液）和三种浓度的CdCl（2）（25、50和100 ppm）。体外研究结果表明，TMC在不同测试浓度下均具有很高的吸附Cd的能力。在水溶液中的吸附范围为可用CdCl（2）的95.7-100％。复杂的TMC-Cd在37°C的不同pH下稳定。体内结果表明，用CdCl（2）（2.5 mg / kg BW）处理2周可导致甘油三酸酯，总蛋白，肌酐，肌酸激酶，免疫球蛋白谱（Ig A和Ig G）和T细胞亚型（CD3（+），CD4（+），CD8（+）和CD56（+））。而它会显着增加血清AST，ALT，LDH的水平，并诱发促炎性细胞因子（TNF-α和IL-1）的变性变化。就所有测试参数而言，单独用TMC（400、600和800 mg / kg BW）治疗的大鼠与对照组相当。 CdCl（2）和TMC的最低剂量（400 mg / kg体重）联合治疗显示所有测试参数都有显着改善。可以得出结论，TMC在低至400 mg / kg体重时可有效预防Cd危害。这些结果支持了我们的假设，即TMC紧密结合并固定了Cd会导致胃肠道金属生物利用度降低。

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