Novel recurrently mutated genes in African American colon cancers

Guda Kishore; Veigl Martina L.; Varadan VinayNosrati ArmanRavi LakshmeswariLutterbaugh JamesBeard LydiaWillson James K. V.Sedwick W. DavidWang Zhenghe JohnMolyneaux NeilMiron AlexanderAdams Mark D.Elston Robert C.Markowitz Sanford D.Willis Joseph E.

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Novel recurrently mutated genes in African American colon cancers

机译：Novel recurrently mutated genes in African American colon cancers

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We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target for mutations in African American CRCs. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes. These previously unsuspected differences in the mutational landscapes of CRCs arising among individuals of different ethnicities have potential to impact on broader disparities in cancer behaviors.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2015年第4期|1149-1154|共6页
作者
Guda Kishore; Veigl Martina L.; Varadan VinayNosrati ArmanRavi LakshmeswariLutterbaugh JamesBeard LydiaWillson James K. V.Sedwick W. DavidWang Zhenghe JohnMolyneaux NeilMiron AlexanderAdams Mark D.Elston Robert C.Markowitz Sanford D.Willis Joseph E.;
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作者单位

Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA;

Case Western Reserve Univ, Div Gen Med Sci Oncol, Cleveland, OH 44106 USA;

Case Western Reserve Univ, Div Hematol & Oncol, Cleveland, OH 44106 USAUniv Texas SW Med Ctr Dallas, Harold C Simmons Comprehens Canc Ctr, Dallas, TX 75390 USACase Western Reserve Univ, Dept Genet & Genome Sci, Cleveland, OH 44106 USAJ Craig Venter Inst, La Jolla, CA 92037 USACase Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
colon cancer; African American; next-generation sequencing; mutation; Caucasian;

Novel recurrently mutated genes in African American colon cancers

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