Diversity, host switching and evolution of plasmodium vivax infecting african great apes

Prugnolle F.; Rougeron V.; Becquart P.Berry A.Makanga B.Rahola N.Arnathau C.Ngoubangoye B.Menard S.Willaume E.Ayala F.J.Fontenille D.Ollomo B.Durand P.Paupy C.Renaud F.

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Diversity, host switching and evolution of plasmodium vivax infecting african great apes

机译：Diversity, host switching and evolution of plasmodium vivax infecting african great apes

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Plasmodium vivax is considered to be absent from Central and West Africa because of the protective effect of Duffy negativity. However, there are reports of persons returning from these areas infected with this parasite and observations suggesting the existence of transmission. Among the possible explanations for this apparent paradox, the existence of a zoonotic reservoir has been proposed. May great apes be this reservoir? We analyze the mitochondrial and nuclear genetic diversity of P. vivax parasites isolated from great apes in Africa and compare it to parasites isolated from travelers returning from these regions of Africa, as well as to human isolates distributed all over the world. We show that the P. vivax sequences from parasites of great apes form a clade genetically distinct from the parasites circulating in humans. We show that this clade's parasites can be infectious to humans by describing the case of a traveler returning from the Central African Republic infected with one of them. The relationship between this P. vivax clade in great apes and the human isolates is discussed.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第20期|8123-8128|共6页
作者
Prugnolle F.; Rougeron V.; Becquart P.Berry A.Makanga B.Rahola N.Arnathau C.Ngoubangoye B.Menard S.Willaume E.Ayala F.J.Fontenille D.Ollomo B.Durand P.Paupy C.Renaud F.;
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作者单位

Laboratoire Maladies Infectieuses et Vecteur: Ecologie, Génétique Evolution et Controle, Unité Mixte de Recherche 224-5290 Centre National de la Recherche Scientifique (CNRS), 34394 Montpellier Cedex 5, France;

Centre de Physiopathologie de Toulouse-Purpan (CPTP), Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1043, Université de Toulouse Paul Sabatier, F-31300 Toulouse, France;

Centre International de Recherches Médicales de Franceville, Franceville, Gabon, GabonParc de la Lékédi, Société d'Exploitation du Parc de la Lékédi, Compagnie Miniere de l'Ogooué, BP 52, Bakoumba, Gabon, GabonDepartment of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, United States;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Emergence; Malaria; Origin; Sylvatic; Transfer;

Diversity, host switching and evolution of plasmodium vivax infecting african great apes

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