A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis

Pedrolli Danielle Biscaro; Kuehm Christian; Sevin Daniel C.Vockenhuber Michael P.Sauer UweSuess BeatrixMack Matthias

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis

【24h】

A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis

机译：A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Flavin mononucleotide (FMN) riboswitches are genetic elements, which in many bacteria control genes responsible for biosynthesis and/or transport of riboflavin (rib genes). Cytoplasmic riboflavin is rapidly and almost completely converted to FMN by flavokinases. When cytoplasmic levels of FMN are sufficient ("high levels"), FMN binding to FMN riboswitches leads to a reduction of rib gene expression. We report here that the protein RibR counteracts the FMN-induced "turn-off" activities of both FMN riboswitches in Bacillus subtilis, allowing rib gene expression even in the presence of high levels of FMN. The reason for this secondary metabolic control by RibR is to couple sulfur metabolism with riboflavin metabolism.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2015年第45期|14054-14059|共6页
作者
Pedrolli Danielle Biscaro; Kuehm Christian; Sevin Daniel C.Vockenhuber Michael P.Sauer UweSuess BeatrixMack Matthias;
展开▼
作者单位

Hsch Mannheim, Inst Tech Microbiol, Dept Biotechnol, D-68163 Mannheim, Germany;

ETH, Inst Mol Syst Biol, CH-8093 Zurich, Switzerland;

Tech Univ Darmstadt, Dept Biol, D-64287 Darmstadt, Germany;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
RibR; FMN riboswitch; Bacillus subtilis; flavin mononucleotide; riboflavin;

A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis

摘要

著录项

相关主题

期刊订阅