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首页> 外文期刊>International immunopharmacology >All creatures great and small: regulatory T cells in mice, humans, dogs and other domestic animal species.
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All creatures great and small: regulatory T cells in mice, humans, dogs and other domestic animal species.

机译：所有生物，大小不一：小鼠，人类，狗和其他家养动物体内的调节性T细胞。

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Abnormalities of peripheral tolerance are thought to contribute to the pathogenesis of a number of inflammatory, autoimmune and neoplastic diseases of both humans and animals. Furthermore, the induction of allograft tolerance is the 'holy grail' of clinical transplantation. Of the various mechanisms underlying peripheral tolerance, regulatory T cells (Tregs) have risen to particular prominence. Various Treg subsets have been characterised, including naturally occurring cells that develop along a regulatory lineage in the thymus and induced cells that arise in the periphery from conventional T cell precursors. The transcription factor Forkhead box (Foxp3) serves a crucial role in stabilising the Treg transcriptome and is a faithful marker of peripheral Tregs in the mouse, though its expression is somewhat more promiscuous in man. Regulatory T cells display a wide spectrum of suppressive and cytotoxic mechanisms and may convert to specific T helper cell subsets in response to appropriate inflammatory cues. Although knowledge of Tregs in domestic animal species is still in its infancy, a growing body of literature is accumulating in the dog, cat, pig, cow, sheep and horse. We highlight our own and other studies of Tregs in the dog, an important veterinary species and a model for a number of human diseases. The ethos of 'One Health, One Medicine' is anticipated to accelerate efforts to close the knowledge gap between domestic animal and mainstream species in this field. We predict that the prodigious pace of research into Tregs will continue unabated for years to come, fuelled by the exciting therapeutic potential of these cells.
机译：人们认为外周耐受性异常促成人类和动物的许多炎性，自身免疫和肿瘤性疾病的发病机理。此外，诱导同种异体移植耐受是临床移植的“圣杯”。在外周耐受的各种机制中，调节性T细胞（Tregs）已特别突出。已经表征了各种Treg亚群，包括沿胸腺中的调节谱系发育的天然存在的细胞和常规T细胞前体在外周产生的诱导细胞。转录因子叉头盒（Foxp3）在稳定Treg转录组中起着至关重要的作用，并且是小鼠外周Treg的忠实标记，尽管它在人体内的表达更为混杂。调节性T细胞显示出广泛的抑制和细胞毒性机制，并可响应于适当的炎症信号而转变成特定的T辅助细胞亚群。尽管家畜中对Treg的了解还处于起步阶段，但在狗，猫，猪，牛，绵羊和马中，越来越多的文献正在积累。我们着重介绍了我们自己和其他对狗中Treg的研究，这是一种重要的兽医物种，也是多种人类疾病的模型。预计“一种健康，一种药物”的精神将加速努力缩小这一领域中家畜和主流物种之间的知识鸿沟。我们预测，在这些细胞令人兴奋的治疗潜力的推动下，对Tregs的研究将继续保持高速增长。

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