Role of surface chemistry in modulating drug release kinetics in titania nanotubes

Mandal Soumit S.; Jose Deena; Bhattacharyya Aninda J.

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Role of surface chemistry in modulating drug release kinetics in titania nanotubes

机译：Role of surface chemistry in modulating drug release kinetics in titania nanotubes

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Surface chemistry and the intrinsic porous architectures of porous substrates play a major role in the design of drug delivery systems. An interesting example is the drug elution characteristic from hydrothermally synthesised titania nanotubes with tunable surface chemistry. The variation in release rates of Ibuprofen (IBU) is largely influenced by the nature of the functional groups on titania nanotubes and pH of suspending medium. To elucidate the extent of interaction between the encapsulated IBU and the functional groups on titania nanotubes, the release profiles have been modelled with an empirical Hill equation. The analysis aided in establishing a probable mechanism for the release of IBU from the titania nanotubes. The study of controlled drug release from TiO2 has wider implication in the context of biomedical engineering. (C) 2014 Elsevier B.V. All rights reserved.

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《Materials Chemistry and Physics》 |2014年第2期|247-253|共7页
作者
Mandal Soumit S.; Jose Deena; Bhattacharyya Aninda J.;
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作者单位

Indian Inst Sci, Solid State & Struct Chem Unit, Bangalore 560012, Karnataka, India;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种英语
中图分类工程基础科学;工程材料学;
关键词
Biomaterials; Nanostructures; Surface properties; Diffusion; ORDERED MESOPOROUS MATERIALS; PORE-SIZE; DELIVERY; MCM-41; BONE; FUNCTIONALIZATION; STRATEGY;

Role of surface chemistry in modulating drug release kinetics in titania nanotubes

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