The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map

Elsen G.E.; Hodge R.D.; Bedogni F.Daza R.A.M.Nelson B.R.Shiba N.Reiner S.L.Hevner R.F.

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The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map

机译：The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map

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The cortical area map is initially patterned by transcription factor (TF) gradients in the neocortical primordium, which define a "protomap" in the embryonic ventricular zone (VZ). However, mechanisms that propagate regional identity from VZ progenitors to cortical plate (CP) neurons are unknown. Here we show that the VZ, subventricular zone (SVZ), and CP contain distinct molecular maps of regional identity, reflecting different gene expression gradients in radial glia progenitors, intermediate progenitors, and projection neurons, respectively. The "intermediate map" in the SVZ is modulated by Eomes (also known as Tbr2), a T-box TF. Eomes inactivation caused rostrocaudal shifts in SVZ and CP gene expression, with loss of corticospinal axons and gain of corticotectal projections. These findings suggest that cortical areas and connections are shaped by sequential maps of regional identity, propagated by the Pax6 → Eomes → Tbr1 TF cascade. In humans, PAX6, EOMES, and TBR1 have been linked to intellectual disability and autism.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第10期|4081-4086|共6页
作者
Elsen G.E.; Hodge R.D.; Bedogni F.Daza R.A.M.Nelson B.R.Shiba N.Reiner S.L.Hevner R.F.;
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作者单位

Center for Integrative Brain Research, Seattle, WA 98101, United States;

Department of Neurological Surgery, University of Washington, Seattle, WA 98195, United States;

Departments of Microbiology and Immunology and Pediatrics, College of Physicians, Columbia University, New York, NY 10032, United States;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Arealization; Bcl6; Bhlhb5; Patterning;

The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map

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