Functional convergence of hopanoids and sterols in membrane ordering

Sáenz J.P.; Sezgin E.; Schwille P.Simons K.

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Functional convergence of hopanoids and sterols in membrane ordering

机译：Functional convergence of hopanoids and sterols in membrane ordering

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Liquid-ordered phases are one of two biochemically active membrane states, which until now were thought to be a unique consequence of the interactions between eukaryotic membrane lipids. The formation of a liquid-ordered phase depends crucially on the ordering properties of sterols. However, it is not known whether this capacity exists in organisms that lack sterols, such as bacteria. We show that diplopterol, the simplest bacterial hopanoid, has similar properties and that hopanoids are bacterial " sterol surrogates" with the ability to order saturated lipids and to form a liquid-ordered phase in model membranes. These observations suggest that the evolution of an ordered biochemically active liquid membrane could have evolved before the oxygenation of Earth's surface and the emergence of sterols.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2012年第35期|14236-14240|共5页
作者
Sáenz J.P.; Sezgin E.; Schwille P.Simons K.;
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作者单位

Max Plank Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany;

Biophysics Group, Biotechnology Center, Technische Universit?t Dresden, 01307 Dresden, Germany;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Bacterial membrane organization; Lipid order; Membrane phase evolution; Organic geochemistry; Polycyclic isoprenoids;

Functional convergence of hopanoids and sterols in membrane ordering

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